双氧化酶1/甲状腺氧化酶1抗体
规格：1尘驳/1尘濒
英文名： DUOX1
别名： Dual oxidase 1; Dual oxidase 1 precursor; DUOX1; EC 1.11.1; EC 1.6.3.1; Flavoprotein NADPH oxidase; Large NOX 1; LNOX1; Long NOX 1; MGC138840; MGC138841; NADPH thyroid oxidase 1; Nicotinamide adenine
分子量： 175kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DUOX1 (1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
双氧化酶1/甲状腺氧化酶1抗体产物介绍：background: Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues. Function: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively双氧化酶1/甲状腺氧化酶1抗体spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene). Subunit: Interacts with TXNDC11, TPO and CYBA. Subcellular Location: Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. Tissue Specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid双氧化酶1/甲状腺氧化酶1抗体, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. Post-translational modifications: N-glycosylated. Similarity: In the N-terminal section; belongs to the peroxidase family. Contains 3 EF-hand domains. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. Gene ID: 53905 Database links: Entrez Gene: 53905 Human Entrez Gene: 99439 Mouse Entrez Gene: 266807 Rat Omim: 606758 Human SwissProt: Q9NRD9 Human SwissProt: Q8CIY2 Rat Unigene: 272813 Human Unigene: 108582 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
双氧化酶1/甲状腺氧化酶1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid