促肾上腺皮质**受体
规格：1尘驳/1尘濒
英文名： ACTHR
别名： ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocortico
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MC2 rece
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞膜
促肾上腺皮质**受体产物介绍：background: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Function: Receptor for ACTH. This receptor is 促肾上腺皮质**受体mediated by G proteins (G(s)) which activate adenylate cyclase. Subunit: Interacts with FALP/MRAP. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Melanocytes and corticoadrenal tissue. DISEASE: Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency促肾上腺皮质**受体, without mineralocorticoid deficiency. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 483980 Dog Entrez Gene: 4158 Human Entrez Gene: 17200 Mouse Entrez Gene: 282839 Rat Omim: 607397 Human SwissProt: Q01718 Human SwissProt: Q64326 Mouse Unigene: 248144 Human Unigene: 426053 Mouse Unigene: 92460 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
促肾上腺皮质**受体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid