胰岛细胞自身抗原1抗体
规格：1尘驳/1尘濒
英文名： ICA1
别名： 69 kDa islet cell autoantigen; Diabetes mellitus type I autoantigen; ICA 1; ICA1; ICA69; ICA69_HUMAN; ICAp69; Islet cell autoantigen 1 (69kD); Islet cell autoantigen 1 69kDa; Islet cell autoantigen 1;
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ICA1
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
胰岛细胞自身抗原1抗体产物介绍：background: Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the ?carbonic anhydrase family encode either active carbonic anhydrase isozymes or 揳catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1胰岛细胞自身抗原1抗体) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences. Function: May play a role in neurotransmitter secretion (By similarity). Subcellular Location: Cytoplasm > cytosol. Golgi apparatus membrane. Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules. Tissue Specificity:胰岛细胞自身抗原1抗体 Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid. Similarity: Contains 1 AH domain. Gene ID: 3382 Database links: Entrez Gene: 3382 Human Entrez Gene: 15893 Mouse Entrez Gene: 81024 Rat Omim: 147625 Human SwissProt: Q05084 Human SwissProt: P97411 Mouse SwissProt: Q63054 Rat Unigene: 487561 Human Unigene: 275683 Mouse Unigene: 1379 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰岛细胞自身抗原1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞类型标志物
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid