Complexin II/复合素2抗体
规格：1尘驳/1尘濒
英文名： CPLX2
别名： Complexin 2; Complexin II; Complexin-2; Complexin2; ComplexinII; CPLX 2; Cplx2; CPLX2_HUMAN; CPX 2; CPX II; CPXII; Hfb1; Synaphin 1; Synaphin-1; Synaphin1; 921 L.
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Complexi
交叉反应：Human, Chicken, Horse,
细胞定位：细胞浆
Complexin II/复合素2抗体产物介绍：background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation)Complexin II/复合素2抗体 following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice. Function: Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. Subunit: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A. Subcellular Location: Cytoplasm; cytosol. Enriched at synaptic-releasing sites in mature neurons. Tissue Specificity: Nervous system. In hippocampus and cerebellum, expressed mainly byComplexin II/复合素2抗体 excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. Similarity: Belongs to the complexin/synaphin family. Gene ID: 10814 Database links: Entrez Gene: 10814 Human Entrez Gene: 12890 Mouse Entrez Gene: 116657 Rat Omim: 605033 Human SwissProt: Q6PUV4 Human SwissProt: P84086 Mouse SwissProt: P84087 Rat Unigene: 193235 Human Unigene: 268902 Mouse Unigene: 10134 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Complexin II/复合素2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid