脑特异性多肽蛋白19抗体
规格：1尘驳/1尘濒
英文名： PCP4
别名： Brain specific antigen PCP 4; Brain specific polypeptide PEP 19; Brain specific polypeptide PEP19; PEP19; Purkinje cell protein 4; PCP-4; PCP4_HUMAN; PEP-19.
分子量： 7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PCP4
交叉反应：Human, Mouse, Rat, Cow, Sheep,
细胞定位：
脑特异性多肽蛋白19抗体产物介绍：background: PCP-4 is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all脑特异性多肽蛋白19抗体 isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome. Function: Probable regulator of calmodulin signaling. Subunit: Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater. Similarity: Belongs to the PCP4 family. Contains 1 IQ domain. Database links: Entrez Gene: 脑特异性多肽蛋白19抗体5121 Human Entrez Gene: 18546 Mouse Entrez Gene: 25510 Rat Omim: 601629 Human SwissProt: P48539 Human SwissProt: P63054 Mouse SwissProt: P63055 Rat Unigene: 80296 Human Unigene: 5023 Mouse Unigene: 9736 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑特异性多肽蛋白19抗体产物应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid